Description
Product Characteristics: FUNCTION: May be involved in NF-kappa-B and MAPK signaling pathways. May be involved in endocytosis. Regulates ENaC surface expression. SUBCELLULAR LOCATION: Golgi apparatus membrane, Multi-pass membrane protein. Endosome membrane, Multi-pass membrane protein. Endosome, multivesicular body membrane, Multi-pass membrane protein. TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in brain, liver, kidney and testis.,Ubiquitination,NFIP2, NEDD4 family-interacting protein 2, Ndfip2
Target Information: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling